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Small molecules, polypeptides, oligonucleotides), the understanding of the disease biology, the screening technology applied, the route ofadministration and the therapeutic area. All of these symp-toms, except the anaesthesia and the pallor of the conjunctiva and iris,are produced by the injection of cocaine as well as by its local applica-fio. Monitoring as a qualitycontrol system during the conduct of clinical trials allows identification ofproblems early on and corrective actions and preventive actions (capas)to be suggested in order to do better in the future. 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